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How should we deal with biotin interference?

Apr 29, 2021

Clinician: Actively ask the patient or their family members whether the patient has taken high-dose biotin medicines/health products (>5,000mcg/day) on the day of treatment. If they do, stop the medicine and wait for a period of time before taking a blood test. For some special populations, such as those with maintenance needs for skin and nails, and patients with multiple sclerosis, it is especially necessary to inquire and identify carefully.

Patients: Know the dosage of biotin supplements you use. If you take high-dose biotin supplements daily, you should stop using them before going to the doctor and inform the attending doctor when you go to the doctor.

The vitamin supplement habits of the general public in various countries are different. For example, the habit of taking vitamin supplements by the American public is more common, while the proportion is lower in China.

In recent years, the development of laboratory testing technology has provided great help for clinical diagnosis and treatment. New biomarker testing can provide more abundant clinical information and improve the accuracy of clinicians' diagnosis and assessment of diseases. However, there are "special" or "exceptional" conditions for any detection technique and symptom performance. As a clinician, on the one hand, we must strengthen learning and update knowledge, and more importantly, we must maintain full communication with patients, combining their symptoms, signs, and medical history. When making comprehensive judgments, you cannot rely solely on a single test index to diagnose and evaluate the disease. When the test results are inconsistent with other indications, you should discuss with laboratory professionals to provide better services to patients.

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