Oleanolic acid is a kind of pentacyclic triterpenoids obtained by separating and extracting from the fruit of the whole plant of the Gentianaceae plant, the genus of the genus Syringa japonica or Ligustrum lucidum. Modern pharmacological studies have confirmed that oleanolic acid can significantly reduce the elevation of serum alanine aminotransferase, alleviate liver cell degeneration and necrosis, liver tissue inflammatory reaction and fibrosis process, promote liver cell regeneration, accelerate the repair of liver necrotic tissue, inhibit the Non-specific inflammatory response, and has the effect of correcting protein metabolism disorders. Ultrastructural observation shows that oleanolic acid can protect and stabilize the lysosomal membrane and the biofilm of organelles, restore its passive permeability and active transport functions, restore the movement of intracellular and extracellular ions and water, and loosen the cytoplasm and balloon-like hepatocytes return to normal, the regeneration ability is enhanced, and liver fibrosis is prevented and inhibited. In vitro experiments showed that oleanolic acid could inhibit the proliferation of leukemia cells by downregulating the expression of vascular endothelial growth factor. It is suitable for the treatment of viral hepatitis, and it can improve symptoms, signs and liver function, correct protein metabolism disorders and have certain anti-tumor effects.
In terms of safety, a small number of cases experienced dry mouth, diarrhea, and upper abdominal discomfort after taking oleanolic acid, which disappeared after symptomatic treatment. Mild thrombocytopenia occurs in individual cases, which can be recovered after stopping the drug.
Matrine is a kind of alkaloid extracted and isolated from Sophora japonica, a plant of the genus Sophora genus, mainly oxymatrine, and contains a small amount of oxymatrine. Matrine has the effect of increasing leukocytes, and also has obvious curative effect on leukopenia; it has protective effect on liver injury, serum alanine aminotransferase is reduced, liver necrosis and inflammation are reduced, and liver tissue repair is increased; in vitro and in vivo experiments show that, It has a certain effect of inhibiting the replication of hepatitis B virus; it can reduce the permeability of capillaries, inhibit the proliferation of granulation tissue, regulate the release of histamine, leukotrienes and other mediators from liver mast cells, and inhibit the release of leukocytes from lipopolysaccharide-induced mouse peritoneal macrophages. Cytokines such as IL-1, interleukin-6, tumor necrosis factor-α, etc., have non-steroidal hormone-like anti-inflammatory and anti-allergic effects; can inhibit the proliferation of hepatic stellate cells and have anti-hepatic fibrosis effects; Immunomodulatory effect, and can effectively prevent or delay the occurrence of liver cancer. It is suitable for the treatment of chronic hepatitis B, hepatitis B fibrosis, leukopenia caused by tumor radiotherapy, chemotherapy and leukopenia caused by other reasons. Adjuvant therapy for acute and chronic eczema and herpes zoster.
In terms of safety, the common adverse reaction of matrine is a transient increase in alanine aminotransferase, which can be improved with continued medication. There may be nausea, vomiting, bitter taste, diarrhea, epigastric discomfort or pain, etc. Occasionally, skin rash, chest tightness, and fever may occur, and the above symptoms generally relieve themselves.
Silibinin is an antioxidant, extracted from a plant called milk thistle, which can stabilize liver cell membranes, protect the enzyme system of liver cells, remove reactive oxygen radicals in liver cells, thereby enhancing liver detoxification ability, Improve liver function and promote liver cell regeneration. The results of pharmacological and toxicological tests show that silibinin has different degrees of protective and therapeutic effects on various types of liver damage caused by liver poisons, anti-tuberculosis drugs, sepsis, etc., and can prevent the elevation of aminotransferase to some extent. effect. Test results show that silibinin can inhibit liver cell proliferation and collagen synthesis, has a certain anti-fibrotic effect, can prevent diabetic complications by enhancing lipid peroxide clearance, and can increase insulin sensitivity in vivo. It is suitable for the treatment of abnormal liver function in toxic and immune liver damage, acute and chronic hepatitis, and alcoholic fatty liver. And have a certain antagonism of liver fibrosis. It has certain preventive and therapeutic effects on diabetes complications and insulin resistance-related diseases. When used to treat fatty liver and liver cirrhosis, it is recommended not to consume too much high-fat food. Maintenance therapy can be used for the treatment of liver damage caused by long-term alcoholism and smoking.
