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Talk about inulin

Jun 17, 2021

Intestinal health is the most widely known benefit of inulin. Inulin is a natural water-soluble dietary fiber, which can hardly be hydrolyzed and digested by gastric acid. It is only used by beneficial microorganisms in the colon to improve the intestinal environment. Therefore, it is used to regulate the intestinal microflora, improve intestinal health, and prevent constipation. The researchers used a single-center, randomized, double-blind, controlled crossover test method to explore the effects of inulin on the symptoms and intestinal flora of 44 healthy volunteers with constipation between 20 and 75 years old. The subjects consumed 12g (3×4g) of inulin or maltodextrin (placebo) daily for 4 weeks. The results showed that the intake of inulin increased the defecation frequency of the subjects, improved intestinal function, greatly increased the content of bifidobacteria in the intestinal microbes, and reduced the population of Biliophilus, thereby producing beneficial diabetic bacteria. Acid salt. Studies have found that daily consumption of vegetables rich in inulin has an impact on the gut microbiota and eating habits of healthy individuals. 26 healthy subjects (18 to 85 years old, BMI: 20 to 25). During the first two weeks of the experiment, the subjects consumed an average of 15g of inulin per day (based on the intake of vegetables rich in inulin) Diet), and then resume normal eating habits for 2 to 3 weeks. It was found that the dietary intervention of inulin increased the proportion of Bifidobacterium in the intestines of the subjects, decreased the level of Clostridium, and decreased the oxalobacteria. The subjects had a stronger feeling of satiety and were more sensitive to sweet, salty and greasy The appetite for food decreases, and the preference for vegetables rich in inulin tends to increase. The researchers fed apolipoprotein E-deficient mice a diet free of n-3 polyunsaturated fatty acids (PUFA) for 12 weeks, and added inulin to the diet for the last 15 days. The results showed that the intake of inulin led to an increase in nitric oxide-producing bacteria, restoration of the abundance of Akk bacteria, a decrease in the abundance of bacterial taxa related to the synthesis of secondary bile acids, and an increase in glucagon-like in the intestine and liver. The expression of peptide-1 and bile acid conversion related genes completely reversed the vascular endothelial dysfunction of the mesenteric and carotid arteries. Studies have shown that the degree of proliferation of bifidobacteria depends on the number of initial bifidobacteria in the human large intestine. When the initial number of bifidobacteria decreases, the proliferation effect is obvious after using inulin. When the initial number of bifidobacteria is large, use chrysanthemum The effect after powder is not obvious. Secondly, the intake of inulin can enhance gastrointestinal motility, improve gastrointestinal function, increase digestion and appetite, and improve immunity. Food reaches the colon after digestion and absorption. Under the action of intestinal saprophytes (E. coli, Bacteroides, etc.), many toxic metabolites (such as ammonia, nitrosamines, phenol and cresol, secondary bile acids, etc.) can be produced ), and the short-chain fatty acids produced by the fermentation of inulin in the colon can lower the pH of the colon, inhibit the growth of saprophytes, reduce the production of toxic products, and reduce the stimulation of the intestinal wall. A series of metabolic activities of inulin can inhibit the production of toxic substances, increase the frequency and weight of bowel movements, increase the acidity of feces, accelerate the excretion of carcinogens, and produce short-chain fatty acids with anti-cancer effects, which is beneficial to the prevention of colon cancer.

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