In rodents, obesity and aging can impair the biosynthesis of nicotinamide adenine dinucleotide (NAD +), leading to metabolic dysfunction. The availability of nicotinamide mononucleotide (NMN) is the rate-limiting factor in mammalian NAD+ biosynthesis.
On April 22, 2021, the team of Samuel Klein of the University of Washington in the United States published a research paper entitled "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women" in Science Online. The study conducted a 10-week randomized, placebo-controlled, A double-blind trial to evaluate the effect of NMN supplementation on the metabolic function of women with overweight or obesity after menopause.
After supplementation with NMN, insulin-stimulated glucose utilization was assessed using a hyperinsulinemic-hyperglycemic clamp. Skeletal muscle insulin signaling (phosphorylation of AKT and mTOR) increased, but did not change after placebo treatment. NMN supplementation up-regulates the expression of platelet-derived growth factor receptor β and other genes related to muscle remodeling. These results indicate that NMN can increase muscle insulin sensitivity, insulin signaling and remodeling in overweight or obese pre-diabetic women.
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