Mifepristone is a synthetic steroid with anti progestational effects indicated for the medical termination of intrauterine pregnancy through 49 days' pregnancy. Doses of 1 mg/kg or greater of mifepristone have been shown to antagonize the endometrial and myometrial effects of progesterone in women. During pregnancy, the compound sensitizes the myometrium to the contraction-inducing activity of prostaglandins. Mifepristone also exhibits anti glucocorticoid and weak antiandrogenic activity. The activity of the glucocorticoid dexamethasone in rats was inhibited following doses of 10 to 25 mg/kg of mifepristone. Doses of 4.5 mg/kg or greater in human beings resulted in a compensatory elevation of adrenocorticotropic hormone (ACTH) and cortisol
Product Name: Mifepristone Powder
Appearance: Straw yellow crystalline powder.
Solubility: Insoluble in water. Free soluble in dichloromethane and in methanol.
Melting point: 192~196
Clarity: Not less than 95% at 650nm.
Specification rotation: +124° to +129° on anhydrous basis
Loss on drying: ≤0.5%
Residue on ignition: ≤0.1%
Heavy metals: ≤20ppm
Related substances: Max individual impurity:≤0.5%
A progesterone receptor antagonist with partial agonist activity. Abortifacient.
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