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API Raw Material Clobetasol Propionate

API Raw Material Clobetasol Propionate

Product name: Clobetasol Propionate
CAS No.:25122-46-7
Appearance: White or almost white crystalline powder
Assay: 99%
Standard: EP/BP/USP
MF: C25H32ClFO5
EINECS No.:246-634-3

Description

Product Description


Clobetasol propionate is a corticosteroid used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus (auto immune skin nodules).


Product name: Clobetasol Propionate 

Appearance: White or almost white crystalline powder

CAS No.:25122-46-7

MF: C25H32ClFO5

Assay: 98%

Grade: Pharmaceutical grade

Shelf life: 2 Years

Storage: Kept in a cool and dry place


Specification:

 Basic Information

Product Name

Clobetasol Propionate

CAS

25122-46-7

Purity

97%-103%

Molecular formula

C25H32ClFO5

Molecular weight

466.97

Standard

USP37

Appearance

white to cream, crystalline powder

Identification

A.confirms to the CRS spectrum

Specific Rotation

+112°~+118°(dried substance)

Related substances(by HPLC)

 Impurity A0.2%

 Impurity B0.3%

 Impurity C0.2%

 Impurity D0.2%

 Impurity E0.5%

 Impurity L0.2%

 Impurity M0.2%

 Unspecified impurities0.10%

 Total impurities1.5%

Loss on drying

 0.5%

Sulfated ash

≤ 0.1%

Assay(by HPLC)

Contains 97.0% to 102.0% of C25H32ClFO5

Calculated on dried basis

 

Residual solvents

 

Ethanol  3000ppm 

Acetone  500ppm 

Pyridine  100ppm 

N,N-Dimethylformamide  100ppm


Function

Clobetasol propionate is used for the treatment of various skin disorders including eczema, psoriasis, and lichen sclerosus. It is also used to treat several autoimmune diseases including alopecia areata, vitiligo, lichen planus (autoimmune skin nodules), and mycosis fungoides (T-cell skin lymphoma).


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